SEM imaging revealed cells attaching to and bridging micro-topological features of the porous constructs, and cell activity was significantly greater for the porous PEEK compared to solid at multiple time points.ģD printing Bone ingrowth Fused filament fabrication PEEK Porosity Triply periodic minimal surface.Ĭopyright © 2020 Elsevier Ltd. Average compressive properties ranged from 210 to 268 MPa for elastic modulus and 6.6-17.1 MPa for yield strength, with strength being greatest for TPMS constructs. μCT imaging showed the porous networks to be open and interconnected, with porous sizes similar (p > 0.05) to the as-designed size of 600 μm. The samples were then imaged via scanning electron microscopy (SEM) to observe cell morphology. The porous PEEK, along with 3D printed solid PEEK, was then seeded with MC3T3-E1 preosteoblast cells for evaluation of cell proliferation and alkaline phosphatase (ALP) activity. The porous layer was 399.6 ± 63. The material characteristics, including porosity, yield strength, and roughness, were evaluated using μCT, static compression testing, and optical profilometry. In this study, a surface-porous PEEK material (PEEK-SP) was created using a melt extrusion technique. The designs of the porous structures were based on a simple rectilinear pattern as well as triply periodic minimal surfaces (TPMS), specifically gyroid and diamond types. zFuse puede ser una herramienta de administración de archivos, y puede usarlo para comprimir / descomprimir / ver imágenes / ver varios libros electrónicos en formato de TXT, PDF, EPUB, etc. This is how PEEK is able to avoid stress shielding, and how the polymer encourages more effective healing in native bone. In this study, we created porous PEEK via clinically-available fused filament fabrication (FFF, 3D printing) and assessed the pore structure morphology, mechanical properties, and biologic response. PEEK is recognized as a suitable implant material for hard tissue application because it possesses a similar flexural modulus to cortical bone, so it bends and bears weight like the body’s own tissues 8. The winning technologies this year were selected based on creativity, innovation, the capacity to solve a critical clinical problem as well as their potential long. Though concerns exist regarding PEEK for orthopaedic implants due to its bioinertness, the creation of porous networks has shown promising results for interaction with surrounding tissue. While Porous metal and porous metal-coated PEEK implants have been used for some time in spine fusion applications, ZFUZE stands out as the first and only bona-fide new biomaterial. Due to its unique and advantageous material properties, polyetheretherketone (PEEK) is an attractive biomaterial for implantable devices.
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